The model for two ion channels can be extended to three or more ion channels. For convenience, we summarize below the other ion channels by a single so-called "leakage channel" having conductivity $g_\mathrm{L}$. Then we have an analogue of an electrical circuit that looks as follows:

In this figure, we have also drawn an imposed current, $I_\mathrm{stim}$. The membrane potentental is defined as $V_m=V_i-V_e$

From Kirchhoff's junction rule it follows that the imposed current $I_\mathrm{stim}$ is equal to the sum of the currents of the ion channels and the capacitor; along with Ohm's law this leads to:

$$\begin{aligned}I_\mathrm{stim}&=I_{\mathrm{C_m}} + I_\mathrm{K}+I_\mathrm{Na}+I_\mathrm{L} \\ &= C_m\frac{dV_m}{dt} + g_\mathrm{\small K} (V_m-E_\mathrm{K})+ g_\mathrm{\small Na} (V_m-E_\mathrm{Na})+ g_\mathrm{\small L} (V_m-E_\mathrm{L})\end{aligned}$$ If we define the resting membrane potential $V_r$ define as $$V_\mathrm{r} = \frac{g_\mathrm{\small K} E_\mathrm{K}+ g_\mathrm{\small Na}E_\mathrm{Na}+ g_\mathrm{\small L}E_\mathrm{L}}{g_\mathrm{\small K} + g_\mathrm{\small Na}+ g_\mathrm{\small L}}$$ and define $$V=V_m-V_r$$ , when we consider the potential difference with the resting membrane potential, then we get the following differential equation (check!) $$I_\mathrm{stim}=C_m\frac{dV}{dt} + (g_\mathrm{\small K} + g_\mathrm{\small Na}+ g_\mathrm{\small L}) V$$ If the stimulus is equal to zero, then the differential equation is the same as that of a discharging capacitor. In a cell that is not at rest, but has, for example, a bonzero starting value of the voltage $V$ at time $t=0$, the voltage will approach the original potential via an exponential decay process, according to the formula $$V(t)=V(0)\cdot e^{-\frac{g_m}{C_m}t}$$ where $g_m$ is equal to the sum of the conductitivities of the ion channels.

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In reality, the situation is even more complicated. For the channel conductivity $g_{\mathrm{ion}}$ one often takes the product of a maximum channel conductivity $G_{\mathrm{ion}}$ and the chance $p$ that the ion channels are open and ion transport possible; this probability depends in many models on the potential and time. We will see this when we discuss the Hodgkin-Huxley model for action potentials in nerve cells.