Bioelektriciteit: Simulaties van neurale modellen (Engelstalig, m.b.v EjsS)
Basic Wilson model
Simulation of the basic Wilson model
Starting from the Hodgkin-Huxley model for action potentials, Wilson reduced it for mammalian neocortical neurons to a two-dimensional dynamical system in the following way. First, he adopted the simplification of the Krinsky-Kokoz-Rinzel model for gate functions: and . Because neocortical neurons show no inactivation of sodium channels, one can even set and . Wilson also combined the sodium channel and the leackage channel into a new single sodium channel. The recovery of the membrane potential can then be described by a dynamic modulation fuctions . The system of equations becomes:
where is the membrane potential, is the Nernst potential for a given ion , and
In order to avoid numerical difficulties, the basic Wilson model is rescaled.
Let then the equations become:
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