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Open course materials Various Science Subjects offered by KdVI and SMASH.

Author: André Heck

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Course content
Bioelectricity
Core principles
THEORY
T
1.
Charge and the electric field
THEORY
T
2.
Electric potential energy
THEORY
T
3.
Capacitor
THEORY
T
4.
Capacitors connected in series and in parallel
THEORY
T
5.
Resistor
THEORY
T
6.
Resistors connected in series and in parallel
THEORY
T
7.
Electric circuits
THEORY
T
8.
Charging a capacitor in an RC circuit
THEORY
T
9.
Discharging a capacitor in an RC circuit
PRACTICE
P
10.
Practising the core principles
3
Electric model of the cell membrane
THEORY
T
1.
Introduction
THEORY
T
2.
The Nernst potential for an ion species
THEORY
T
3.
Simulations of the Nernst potential
PRACTICE
P
4.
Calculating the Nernst potential
2
THEORY
T
5.
An electrical analogue of a single ion species and ion channel
THEORY
T
6.
Membrane potential for two ion species and ion channels
THEORY
T
7.
Simulations of the membrane potential for two ion species
THEORY
T
8.
Membrane potential when three or more types of ion channels are involved
THEORY
T
9.
The Goldman-Hodgkin-Katz voltage equation
PRACTICE
P
10.
Computing the resting membrane potential and membrane properties
8
Electric excitability and action potential
THEORY
T
1.
What is an action potential?
THEORY
T
2.
The electric analogue of the model of Hodgkin and Huxley
THEORY
T
3.
Space-clamp and voltage-clamp experiments
THEORY
T
4.
Voltage-dependent conductivity of potassium channels
THEORY
T
5.
Voltage-dependent conductivity of sodium channels
THEORY
T
6.
The model of Hodgkin and Huxley in all its glory
THEORY
T
7.
Simulation of the Hodgkin-Huxley model in R
THEORY
T
8.
Simulation of the Hodgkin-Huxley model
THEORY
T
9.
Refractory period
Passive and activve current flow along an axon
THEORY
T
1.
Passive current flow and the cable equation
THEORY
T
2.
Propagation of an action potential
PRACTICE
P
3.
Computations about the propagaton of an action potential
2
Simulation of several single neuron models
THEORY
T
1.
Hodgkin-Huxley model
THEORY
T
2.
Krinsky-Kokoz-Rinzel model
THEORY
T
3.
Basic Wilson model
THEORY
T
4.
Full Wilson model
THEORY
T
5.
FitzHugh-Nagumo model
THEORY
T
6.
Izhikevich model
Chemical reaction kinetics
Introduction
THEORY
T
1.
Kinetics of the simple chemical reaction A → B
THEORY
T
2.
Simulation of first-order kinetics
THEORY
T
3.
A concrete example of a first-order chemical reaction
Basic principles
THEORY
T
1.
Reaction rate
THEORY
T
2.
Kinetics of an elementary reaction
THEORY
T
3.
An equilibrium reaction
PRACTICE
P
4.
Kinetics of elementary reactions
5
Second-order kinetics
THEORY
T
1.
Kinetics of the reaction 2A → B
THEORY
T
2.
Kinetics of the reaction A + B → C
THEORY
T
3.
Autocatalysis: A + B → 2B
Kinetics of multi-step reactions
THEORY
T
1.
Successive reactions: A → B → C
THEORY
T
2.
Successive reactions:
A → B, B + C → D and A → B, 2B → C
THEORY
T
3.
Dimerization 2A ⇄ B
THEORY
T
4.
Enzymatic reaction kinetics
THEORY
T
5.
Alcohol metabolism
THEORY
T
6.
The Hill equation
PRACTICE
P
7.
Kinetics of multi-step reactions
3
Gene regulation
Introduction
THEORY
T
1.
Introduction
THEORY
T
2.
Gene expression with an activating transcription factor
THEORY
T
3.
Gene expression with an inactivating transcription factor
Dynamical system for proteins
THEORY
T
1.
Gene expression in combination with protein degradation I
THEORY
T
2.
Gene expression in combination with protein degradation II
THEORY
T
3.
Gene expression with negative feedback
THEORY
T
4.
Gene expression with positive feedback
THEORY
T
5.
Gene regulation of oscillations
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Open course materials Various Science Subjects offered by KdVI and SMASH.

Author: André Heck

Full access via UvAnetID

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